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KMID : 0605720060120020146
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Journal of the Korean Society of Biological Therapies in Psychiatry
2006 Volume.12 No. 2 p.146 ~ p.152
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Heat Shock Protein 70(HSP70) Gene Polymorphism in Schizophrenic Patients
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Lee Dae-Ho
Lee Sun-Woo
Wang Seong-Keun
Shin Yun-O
Chee Ik-Seung
Kim Ji-Wook
Kim Jeong-Ran
Lee Young-Ho
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Abstract
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Objectives：The heat shock protein 70(HSP70) is believed to be involved in the pathogenesis of schizophrenia with regards to neurodevelopment. An aberration in the HSP70 has been proposed in schizophrenia patients, suggesting that it is a candidate gene for schizophrenia. This study aimed to investigate the association between polymorphsims of HSP70-2(HSPA1B) and schizophrenia.
Methods：One hundred and four patients with schizophrenia and One hundred and seven normal controls were enrolled in the study. A polymerase chain reaction(PCR) with restriction fragment length enzyme(RFLP) was used to genotype the HSPA1B polymorphisms.
Results：1) In schizophrenic patients, genotype distributions of the HSPA1B polymorphism were AA 32(30.8%), AG 57(54.8%) and GG 15(14.4%), and allele frequencies were A 121(58.2%), and G 87(41.8%). In normal control, genotype distributions of the HSPA1B polymorphism were AA 35(32.7%), AG 63(58.9%) and GG 9(8.4%), and allele frequencies were A 133(62.1%), and G 81(37.9%). There were no significant differences in the allelic or genotype frequencies of the HSPA1B polymorphisms between the schizophrenia patients and the controls. 2) There were no difference in genotype distribution and allele frequencies of the HSPA1B polymorphism, when patients were categorized by sex, family history of psychiatric disease, severity of symptom with PANSS scale.
Conclusion：These results suggest a HSPA1B polymorphism is not causally related to the pathogenesis of schizophrenia in the Korean population. Further study of HSPA1B polymorphism should be needed, including family based association study and other clinical variations of schizophrenia.
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KEYWORD
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Heat shock protein, Gene polymorphism, Schizophrenia
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